(S)-tert-butyl 2-oxopiperidin-3-ylcarbamate - Names and Identifiers
Name | tert-butyl [(3S)-2-oxopiperidin-3-yl]carbamate
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Synonyms | (S)-3-BOC-AMINO-2-PIPERIDONE (S)-3-Boc-aminopiperidin-2-one t-Butyl (S)-2-oxopiperidin-3-ylcarbamate 3-tert-butyloxycarbonylamino-2-piperidone (S)-tert-butyl2-oxopiperidin-3-ylcarbamate (S)-tert-butyl 2-oxopiperidin-3-ylcarbamate N-tert-butyl-N-(2-oxopiperidin-3-yl)carbaMate tert-butyl [(3S)-2-oxopiperidin-3-yl]carbaMate tert-butyl [(3S)-2-oxopiperidin-3-yl]carbamate tert-butyl N-[(3S)-2-oxopiperidin-3-yl]carbaMate Carbamic acid, N-[(3S)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester
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CAS | 92235-39-7 99780-98-0
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InChI | InChI=1/C10H18N2O3/c1-10(2,3)15-9(14)12-7-5-4-6-11-8(7)13/h7H,4-6H2,1-3H3,(H,11,13)(H,12,14)/t7-/m0/s1 |
(S)-tert-butyl 2-oxopiperidin-3-ylcarbamate - Physico-chemical Properties
Molecular Formula | C10H18N2O3
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Molar Mass | 214.26 |
Density | 1.11±0.1 g/cm3(Predicted) |
Melting Point | 203-205 °C |
Boling Point | 405.6±34.0 °C(Predicted) |
Flash Point | 199.1°C |
Vapor Presure | 8.68E-07mmHg at 25°C |
pKa | 11.05±0.20(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.489 |
(S)-tert-butyl 2-oxopiperidin-3-ylcarbamate - Introduction
tert-butyl [(3S)-2-oxopiperidin-3-yl]carbamate is an organic compound with the chemical formula C11H19N3O3. It is a white solid with relatively low solubility. It is a derivative of an amino acid protecting group and is commonly used as an intermediate in organic synthesis.
tert-butyl [(3S)-2-oxopiperidin-3-yl]carbamate has a variety of applications. First of all, it is commonly used as a protecting group in peptide synthesis, which can protect amino acids in organic synthesis and prevent accidental side reactions during synthesis. Secondly, it can also be used as an important intermediate in drug synthesis. In addition, it can also be used in biological activity research and drug development.
The preparation method of tert-butyl [(3S)-2-oxopiperidin-3-yl]carbamate is complicated. It can be obtained by reacting (S)-3-amino-2-piperidone with tert-butyl iodoacetate (tert-butyl chloroformate). The reaction conditions are generally at room temperature with the addition of a base catalyst. Finally, the pure product can be obtained by crystallization purification.
Regarding safety information, tert-butyl [(3S)-2-oxopiperidin-3-yl]carbamate is a relatively safe compound under general operating conditions. However, like many chemicals, it can be irritating to the skin, eyes and respiratory system. Therefore, the use should follow the relevant laboratory practices, wear appropriate personal protective equipment, avoid direct contact and inhalation. In case of any doubt or emergency, you should immediately turn to a professional.
Last Update:2024-04-09 21:01:54